Diabetes mellitus is considered, the sixth main cause of death throughout the world, and every
ten seconds a person dies from causes related to diabetes, mainly due to cardiovascular
complications. Mushrooms have been used for traditional foods and medicines globally. The
current study was tried to evaluate the in-vitro anti-oxidant and antidiabetic properties of
methanolic extracts of the Agaricus biosporus and coprinus comatus using alpha (Î±)-amylase,
beta (Î²)-glucosidase assays and anti-oxidant efficacy by applying ABTS and DPPH radical
scavenging assays. The Agaricus biosporus methanolic extracts (ABME) showed significant
inhibitory effects of DPPH (0.48± 0.002) and ABTS (0.11 ±0.01) and C.comatus DPPH
(2.50±0.12) ABT (3.16±1.4) with an IC50 value respectively as compare with standard drug
ascorbic acid. The selected mushrooms species methanolic extracts exhibited significant
inhibitory activities of Î²-glucosidase and Î±-amylase having IC50 value at a concentration of
0.75Î¼g , 0.80Î¼g extracts in the same way as compared with the standard drug Glucophage. Our
results suggest that the Agaricus biosporus and coprinus comatus mushroom could be useful for
the control of diabetes and free radicals produced by different metabolic activities in our body.
Medicinal mushrooms, C. comatus, A. bisporus, Î±-amylase, Î²-glucosidase, DPPH,
ABTS, anti-oxidanti, anti-diabetic potential.
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