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J Complement Med Res. 2016; 5(3): 320-324

Evaluation of Anti-Inflammatory and Analgesic Effects of Pioglitazone and Rosiglitazone in Wistar Rats

C. C. Khanwelkar, Abhay A. Purohit, S. A. Jadhav, Sheshla Sadanandan, Pritam Sakhare.


The challenges faced in the treatment of various inflammatory disorders are immense. Inflammation is emerging as the pathological basis for many disorders like rheumatoid arthritis, uveitis etc. The purpose of the study is to evaluate analgesic effect of the test drugs Pioglitazone, Rosiglitazone and the standard drug Diclofenac sodium using Analgesiometer, in Wistar rats. NSAIDs and steroidal anti- inflammatory drugs have yielded good results in the treatment of inflammatory conditions, except for their potential to produce serious adverse effects, have resulted in widespread limitation of their use. In this study three models were selected for evaluation of acute and sub-acute anti- inflammatory activity, as well as analgesic activity of test drugs, Pioglitazone and Rosigliitazone. For comparison Diclofenac was used as a standard drug and vehicles of each test drug were used as control. Wistar rats were used as experimental animals.

Key words: Anti-Inflammatory, Analgesic, Wistar rat, Pioglitazone, PPAR-gamma

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