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Kawasaki's disease as a consequence of SARS-COV-2 infection: physiopathological relationships and clinical manifestations

Barbara Arajo de Figueiredo Toledo, Isadora Silva dos Anjos, Julia Teoro Mansano, Leticia Dias Escoura, Raianny Cunha Duarte, Douglas Reis Abdalla.

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COVID-19 has already affected more than 34 million people and led to the death of 1 million of them. The most serious cases that lead to death usually occur in people with comorbidities such as obesity, hypertension and diabetes. However, it has been observed that children with COVID-19 later show signs and symptoms that resemble Kawasaki's Disease (DK). The present study aims to recruit evidence about the relation of COVID-19 as a triggering factor for manifestations of DK, especially vasculitis. Infection with the SARS-COV-2 virus can both mimic DK symptoms, since an excessive immune response to the virus is capable of stimulating interferons and the STING pathway, which triggers exacerbated immune responses, decreased lymphocytes, increased B and T cell responses, and increased monocytes secreting cytotoxins, facts that corroborate the characteristic vasculitis of DK. Therefore, there is no concrete scientific evidence/ evidence of the association between the diseases, however, factors have been discussed that suggest that the SARS-COV-2 virus may be a trigger for Kawasaki-like vasculitis in children, reported in several countries in the COVID-19 pandemic.

Key words: Kawasaki’s Disease, SARS-COV-2, Vasculitis, Child

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