Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Article



Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats

Saber A. Sakr, Hoda A. Mahran, Marwa M. El-Deeb.

Cited by (1)

Abstract
Fluoxetine is a selective serotonin reuptake inhibitor used to treat depression and mood disorders. Curcumin, the major active ingredient of turmeric (Curcuma longa), showed many pharmacological effects and is known for its potent antioxidant capacity. The present work aims to evaluate the possible ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in albino rats. Histological examination of testis of fluoxetine-treated rats revealed degeneration of spermatogenic cells, congestion of blood vessels and destruction of Leydig cells. In addition, speramatogenesis was inhibited as indicated by the decrease of the number of different spermatogenic cells. The diameters of the seminiferous tubules and heights of their germinal epithelium were significantly reduced. Moreover, significant higher numbers of Bax-positive Leydig cells were recorded. Testosterone, luteinizing hormone (LH) and glutathione (GSH) were decreased while malondialdehyde were increased in sera of fluoxetine-treated animals. Treating animals with fluoxetine followed by curcumin revealed an improvement in the histological changes observed in animals treated with fluoxetine. Moreover, curcumin treatment leads to decrease in the number of Bax-positive cells, increase in testosterone, LH, GSH, and decrease of lipid peroxidation. According to the present results, it can be concluded that combined treatment with fluoxetine and curcumin can improve the testicular abnormalities induced by fluoxetine. This effect of curcumin may be attributed to its antioxidant properties.

Key words: Bax; Curcumin; Fluoxetine; Lipid peroxidation; Testis



Similar Articles

Cholesterol synthesis inhibition or depletion in axon regeneration.
Tang BL
Neural regeneration research. 2022; 17(2): 271-276

The surface of lipid droplets constitutes a barrier for endoplasmic reticulum-resident integral membrane proteins.
Khaddaj R, Mari M, Cottier S, Reggiori F, Schneiter R
Journal of cell science. 2022; 135(5):

Dissecting lipid droplet biology with coherent Raman scattering microscopy.
Chen T, Yavuz A, Wang MC
Journal of cell science. 2022; 135(5):

Characterization of micron-scale protein-depleted plasma membrane domains in phosphatidylserine-deficient yeast cells.
Mioka T, Guo T, Wang S, Tsuji T, Kishimoto T, Fujimoto T, Tanaka K
Journal of cell science. 2022; 135(5):

Spectral fitting strategy to overcome the overlap between 2-hydroxyglutarate and lipid resonances at 2.25 ppm.
Askari P, Dimitrov IE, Ganji SK, Tiwari V, Levy M, Patel TR, Pan E, Mickey BE, Malloy CR, Maher EA, Choi C
Magnetic resonance in medicine. 2021; ():


Full-text options


Add your Article(s) to Indexes
• citeindex.org






ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.