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PBS. 2013; 3(3): 93-9

Oxidative parameters in bipolar patients treated with electroconvulsive therapy and pharmacotherapy

Mahmut Bulut, Abdurrahman Altındağ, Zeliha Deveci, M. Cemal Kaya, Feridun Bülbül, Abdullah Taşkın, Şengül Kocamer, Haluk A. Savaş.

Electroconvulsive (ECT) is one of the most efficacious choice in the treatment of bipolar disorder. There is no study conducted on human being investigating the effect of ECT on oxidative balance in bipolar disorder. In the present study, we aimed to evaluate the oxidative parameters on bipolar inpatients who is treated with ECT and pharmacotherapy. 31 bipolar inpatients in psychiatry department of Gaziantep University and 35 healty volunteeers were included in the study. Total Antioxidant Status (TAS), Total Oxidant Status (TOS) of serum samples were measured and Oxidative Stress Index (OSI) were counted in Harran University Biochemistry Laboratory.
In all patient group, bipolar manic episode and depressive episode patients; before ECT and after ECT there was no significant difference for oxidative parameters. Before ECT, TAS levels in bipolar depressive episode patients were significantly lower than the control group (z=-2.614, p=0.009). But after ECT, there was no difference between these two groups (z=-1.558, p>0.05).
Before ECT, TOS levels in bipolar manic episode patients were significantly higher than the control group (z=-2.598, p=0.009); after ECT, there was no difference between these two groups (z=-0.910, p>0.05).
Finally, when compared with controls, in bipolar depressive episode patients TAS levels were increased with ECT and pharmacotheraphy and in bipolar manic episode patients TOS levels were decreased. For more comprehensive results new studies are needed.

Key words: bipolar disorder, electroconvulsive therapy, oxidative parameters, combined treatment, oxidative parameters

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