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Antibiotic resistance patterns of Pseudomonas aeruginosa in a tertiary care hospital in Central India

Vijaya Chaudhari, Sandeep Gunjal, Mukesh Mehta.

Background: Antimicrobial resistance is the major problem of the modern world, thus it needs urgent attention. Pseudomonas aeruginosa has the inherent property of developing the resistance. Hence, it is necessary to know the current resistance pattern for proper use of antipseudomonal agents.

Aims & Objective: (i) To evaluate the antibacterial resistance pattern in Pseudomonas aeruginosa in a tertiary care hospital in Central India; (ii) To provide base for formulating rational antibacterial guidelines to treat the infections caused by pseudomonas aeruginosa.

Material and Methods: The present study was an observational, longitudinal study over a period of three years from April 2007 to March 2010. The necessary data was obtained from Central Microbiology Laboratory of Government Medical College, Nagpur, India. Total 1001 samples were reported the presence of Pseudomonas aeruginosa in all the 11 types of biological sample. Antimicrobial susceptibility testing was performed using disk diffusion method with Pseudomonas species ATCC 27853, as per CLSI guidelines. Appropriate statistical analysis methods were applied to the data to fulfil the objectives of the study with the latest version of Graph pad prism software.

Results: Pus samples showed highest culture positivity for P. aeruginosa followed by sputum. The highest resistance was reported to ciprofloxacin while the lowest resistance to Meropenem.

Conclusion: Wound infection was the most common hospital acquired infection. The use of Meropenem and Amikacin should be restricted to avoid the emergence of resistance against them. Such studies should be performed regularly to recognize the recent trends.

Key words: Amikacin; Antibiotic Susceptibility Testing; Antipseudomonal Agents; Ciprofloxacin; Meropenem

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