Abstract

Background:
Canine hemangiosarcoma (HSA) is a highly malignant tumor originating from endothelial cells that frequently affects the spleen with rapid metastatic spread. Although metastases commonly involve the lungs and liver, brain involvement is rare.

Case Description:
Splenic HSA with extensive metastasis in a 7-year-old male Doberman is described. The dog was referred with lethargy, anorexia, and walking incoordination. Radiographic and ultrasonographic examination confirmed liver and lung metastases. Necropsy revealed multiple dark-red nodules in the spleen, lungs, and central nervous system, including the cerebrum and cerebellum.

Conclusion:
In the histopathologic investigation, HSA was diagnosed. Irregular vascular channels lined the proliferative endothelial cells containing erythrocytes, and pleomorphism was observed. Because canine HSA is analogous to human angiosarcoma, further studies are needed to explore targeted therapies that could enhance survival in both species.

Key words: Dog; Hemangiosarcoma; Metastasis; Pathology.