Health care remains a sector of paramount importance that needs urgent innovation and further transformation in the face of current challenges. Information technologies and capabilities of artificial intelligence should be widely used to form integrated innovative models of the health care system. Governments, providing state support for transformational changes, play a leading role in unlocking the potential of these technologies. There is no doubt that the COVID-19 pandemic will make adjustments to the management model and financing of the health care sphere. The academic paper has analyzed the current state of readiness of health care systems of the studied countries to withstand the challenges and crises in the medical sphere on the basis of the Global Health Index (GHSIndex). Despite the fact that countries that are classified as high-income countries have higher GHSIndex values than poor countries, no causative-consecutive interconnection was found between public spending on health care and its effectiveness. The influence of the application of modern managerial approaches and possibilities of information technologies and artificial intelligence on the transformation of health care systems, reorienting them to the integrated human-centered and value model has been investigated. A conceptual model and principles of transformation of the medical sphere have been compiled in accordance with current challenges, based on the implementation of new approaches in health care management, namely: value, human-centric and holistic, for further research into the mechanisms of transformation of the medical sphere through new interdisciplinary links, methodological developments, and theoretical foundations.
Key words: Medical Sphere; Health Care System; Human-Centered Approach; Integrated System; eHealth, Value Creation