Abstract

Consuming a diet high in sugar is linked to the development of hyperglycemia, hyperlipidemia, insulin resistance, type 2 diabetes, and obesity. This study aimed to evaluate the protective role of lemongrass extract against metabolic dysregulation caused by a high-sugar diet in mice. Six-week-old male Swiss albino mice (n = 24) were divided into four groups: normal diet (ND), normal diet + lemongrass extract (ND+LGE), high sugar diet (HSD), and high sugar diet + lemongrass extract (HSD+LGE). Throughout the study, food intake, water consumption, and body weight (BW) were monitored. At the end of the study, organ weights, intraperitoneal glucose tolerance test (ipGTT), lipid profile, and histological examination of the liver tissues were performed. The results revealed that LGE significantly decreased food intake, body weight, and the weight of the liver and white adipose tissue (WAT) in HSD-fed mice. Furthermore, HSD-fed mice treated with LGE exhibited improved ipGTT results and lower glucose levels compared to the HSD control group. LGE also reduced the levels of TC, TAG, and LDL in mice fed with HSD. These results indicate that LGE has ameliorative properties that can help to manage HSD-induced metabolic disorders in mice. Therefore, lemongrass could be used as a medicinal herb to correct the metabolic dysregulation caused by HSD.

Key words: Lemongrass, Metabolic disorders, High-sugar diet, Hyperglycemia, Obesity