Osmotic Demyelination Syndrome is a rare neurological condition caused by a number of clinical conditions and with a wide spectrum of clinical features. This case series describes three cases admitted to our hospital and looks at their clinical profile including aetiology, clinical features, imaging findings and outcomes after treatment. Rapid correction of sodium and alcoholism were found to be the main etiologies. Clinical presentation included symptoms like altered sensorium, dysarthria, extrapyramidal symptoms, pyramidal involvement and movement disorders. Imaging done showed symmetrical lesions involving the pons and the basal ganglia. The treatment was supportive in nature and outcomes were good in most of the cases. Early identification of this condition and treatment is key to good long-term outcomes.
Key words: Osmotic Demyelination Syndrome, Central Pontine Myelinolysis, Extrapontine Myelinolysis,
Hyponatremia, Alcoholism
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