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Pharmacological evaluation of ethnomedicinal Glycosmis pentaphylla Lour. as antidiabetic, antioxidant and cytotoxic agent

Mohammad Oliur Rahman, Mohammad Badiur Rahman, Shah Alam Siddiqui, Mohammad Abul Hassan, Mohammad Abdur Rashid.

Abstract
In this study an ethnomedicinal plant Glycosmis pentaphylla Lour. has been investigated for its pharmacological potential including antidiabetic, antioxidant and cytotoxic activities. In the investigation for antidiabetic activity, diabetic induced rats received methanolic extract repeatedly for consecutive three weeks. The blood glucose level was reduced to 33.82%, 24.38% and 9.596% after 7 days, 14 days and 21 days of treatment, respectively. In this case, statistically significant (P< 0.05) blood glucose lowering potential of methanol leaf extract at dose of 250 mg/kg body weight was found. In DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assessment, moderate antioxidant activity was observed in the crude methanol extract with IC50 value of 46.75 g/mL. In brine shrimp lethality evaluation, the methanol extract showed significant cytotoxicity with LC50 value of 22.55 g/mL. Our study testifies that methanol extract of Glycosmis pentaphylla has promising pharmacological activities and explored this species as a potential source of active secondary metabolites for pharmaceutical and agrochemical industries.

Key words: Antidiabetic, DPPH, Brine shrimp lethality, Cytotoxicity, Glycosmis pentaphylla.



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