Home|Journals|Articles by Year

Directory for Medical Articles
 

Original Article



Optimum synthesis of CuO nanoparticles with the highest antifungal activity against Oral Pathogen Candida albicans

Mohammad Moslem Imani, Mohsen Safaei, Hedaiat Moradpoor, Razieh Rezaei, Amin Golshah, Farzad Rezaei, Ladan Jamshidy.


Abstract

This research was aimed to optimize the synthesis of copper oxide (CuO) nanoparticles with the highest antifungal properties against Candida albicans as an oral fungal pathogen. To this end, nine experiments involving different synthesis conditions designed using the Taguchi method and the copper oxide nanoparticles synthesized by coprecipitation method. The antifungal activity of synthesized nanoparticles against Candida albicans was evaluated using the colony forming unit (CFU) and disk diffusion methods. According to the results, the synthesized copper oxide nanoparticles under the experiment 5 conditions (CuCl2 0.1 M, NaOH 0.1 M, and a 75 min stirring time) showed the highest antifungal activity against Candida albicans (71.72%). The optimization results demonstrated, all three studied factors were effective in improving the antifungal activity of copper oxide nanoparticles and the antifungal activity in the proposed conditions can be improved by 77.85%. The synthesis of nanoparticles in optimal conditions confirmed the improved antifungal activity of the nanoparticles. The results of this study proved that CuO nanoparticles have a potential ability as an antifungal agent against oral fungal pathogens of Candida albicans.

Key words: Antifungal activity, CuO nanoparticles, Oral Pathogen, Candida albicans, Taguchi method, Biomedical application






Full-text options


Share this Article



Online Article Submission
• ejmanager.com







eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.