Abstract

Ciprofol and propofol are two intravenous anesthetics that are used for procedure sedation and have different pharmacological characteristics. Hysteroscopy is a gentle, non-invasive gynecological operation that requires proper and safe anesthesia to ensure a patient's comfort and the success of the operation. This meta-analysis and systematic review evaluated the efficacy and safety of ciprofol against propofol sedation for hysteroscopy. An intensive search of PubMed, Scopus, Web of Science, and the Cochrane Library yielded randomized controlled trials comparing the two agents. Random-effects models were used to evaluate five studies (a total of 1718 patients). The ciprofol was linked to a significantly lower frequency of respiratory depression, hypoxemia (RR = 0.34, 95% CI 0.25-0.46), hypotension (RR = 0.58, 95% CI 0.50-0.67), and injection discomfort (RR = 0.15, 95% CI 0.06-0.36) with a high level of statistical significance. There was a slight reduction in the heart rate in the ciprofloxacin group five minutes after induction, and mean arterial pressure was significantly raised after sensitivity analysis. The sedative success rates of propofol and ciprofol did not differ significantly. In general, the evidence suggested that ciprofol is just as effective and had a better safety profile than propofol in the hysteroscopy sedation context and is therefore a promising candidate to improve safety and patient outcomes of the procedure.

Key words: Ciprofol, propofol, hysteroscopy, sedation, systematic review, meta-analysis.