Abstract

A genetic illness called familial adenomatous polyposis (FAP) is marked by the growth of several colon and rectum polyps, which can cause colorectal cancer. Though non-metastasizing, desmoid tumors (DTs) are a frequent and possibly deadly extra-intestinal manifestation of FAP whose pathophysiology is unknown. This systematic review aimed to assess the prevalence, risk elements, and available treatment choices for desmoid tumors in FAP patients. Total 26 studies including 12,077 FAP patients were systematically reviewed. The studies varied in design, including retrospective cohort studies (17 studies), cross-sectional studies (9 studies), and others. Information on tumor location, APC mutation sites, family history, earlier surgeries, and gender was gathered. Desmoid tumors' pooled prevalence was examined together with their related risk factors. Furthermore, investigated in the study investigated the qualities of tumors, like size and anatomic location. The cumulative prevalence of desmoid tumors in FAP patients was 14.1% (95% CI: 12%-16%). With a much reduced likelihood of desmoid tumor development in males (OR = 0.71, 95% CI: 0.62–0.83, p

Key words: Systematic review, adenomatous polyposis, patients with familial adenomatous polyposis, predicting desmoid.