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Correlation Of APACHE-II Scoring, CRP Levels, Il-6 Estimation And Contrast Enhanced Computed Tomography Severity Index For The Early Prediction Of Severity And Morbidity In Acute Pancreatitis

Shaurya Pratap Singh, Priyanka Rai, Amarjot Singh, Sunil Kumar SIngh, Rohit Srivastava, Vaibhav Raj Gopal.

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Acute pancreatitis is a common and challenging disease that can develop both local and systemic complications. Most patients develop a mild and self-limited course; however, 10% to 20% of patients have a rapidly progressive inflammatory response associated with prolonged length of hospital stay and significant morbidity and mortality. The first four days are crucial in the evolution of acute pancreatitis, during which 15 to 25% of patients develop the severe form of disease3. Early aggressive and intensive treatment in the first phase can improve survival if one can predict the severity at an early stage
The aim of the study is to correlate APACHE-II scoring, C-Reactive Protein levels, Interleukin-6 estimation and Computed Tomography Severity Index in assessing the severity of acute pancreatitis.
Prospective Observational Comparative Pilot Study.
Statistical Analysis: Mcnamer tests were used to compare sensitivity and specificity of APACHE II scoring, CRP, IL 6 estimation and contrast-enhanced CT findings
Results: APACHE II at admission (p=0.004), at 72 hours (p

Key words: Acute Pancreatitis, APACHE-II, CRP, II-6 , Contrast CT score

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