Lithium is a mood stabilizer commonly used to treat and prevent mania attacks in bipolar disorder. One of the many side effects that can be seen in lithium treatment is edema. Cases with lithium-induced edema are important because they can be seen even at normal serum lithium concentration. When edema is seen in the face, hands, trunk and extremities in a patient using lithium, lithium can be considered the cause of edema if there is no underlying kidney, heart or liver dysfunction. In this study, we aimed to discuss bilateral pitting-type pretibial edema and periorbital edema after lithium treatment that was begun after a manic episode. The therapeutic range of lithium is narrow, and edema is less common than other side effects. The clinical path that should be followed in patients with no etiological cause and who are considered to have lithium-related edema is controversial. This is the first case in which lithium-associated periorbital edema has been reported.
Key words: Lithium, Pretibial and Periorbital Edema, Bipolar Disorder
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