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Review Article

SRP. 2020; 11(1): 69-75

The Interfering Effects of PD-1 and TIPE2 in Bronchial Asthma

Nawras Najah Mubark, Kareem Hamed Ghali, Jafar A. Al-maamori.


Asthma is a chronic reversible airway disease, results from genetic – environmental interaction. Inflammatory processes may aggravate the severity of asthma and stimulate the airway remodeling. The aim of the current study is to evaluate the association between the negative inflammatory regulators; tumor necrosis factor α induced protein 8 like 2 (TIPE2) and Programmed cell death-1 (PD-1 with bronchial asthma in Iraqi population. blood samples are collected from 100 patients diagnosed with bronchial asthma (59 females and 41 males), their ages ranged between 2 to 61 years and 30 healthy individuals (14 females and 16 males) with the same age range. DNA extracted and then subjected to real time PCR for detection of gene expression. TIPE2 and PD-1 have low folding change of genes expression in asthmatic patients (0.01 and 0.10 respectively) compared to healthy control (1.00) which is reflect the significant differences (p

Key words: asthma, TIPE2, PD-1, gene expression

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