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Review Article

SRP. 2020; 11(1): 51-57


Evaluation Gene Expression of Stem Cell Factor and C-kit among Bronchial Asthmatic patients

NAWRAS NAJAH MUBARK, JAFAR A. AL-MAAMORI, KAREEM HAMED GHALI.




Abstract

Background: Mast cells play an essential role in pathology of bronchial asthma. Stem cell factor (SCF) is a major mast cell growth factor, which could be involved in the local increase of mast cell number in the asthmatic airways when bind to its receptor (C-kit). Existing study aimed to evaluate role of gene expression of SCF and their receptor C-kit in development of bronchial asthma in Iraqi population.
Methods: present study included 100 patients diagnostic with bronchial asthma (59 females and 41 males) their ages range from 2 to 61 years and 30 healthy individuals (14 females and 16 males) with the same age range as control group DNA extracted from whole blood samples and then subjected to real time PCR for detection of gene expression.
Results: current data showed a significant correlation (p0.05) . The optimum cut-off values for gene expression of SCF and C-kit are ≥ 0.55, ≥2.328 respectively since there are associated with a perfect test for predicting asthma.
In conclusion: high gene expression of SCF and C-kit associated with increase severity stage of bronchial asthma without treatment and can be reduced by treatment.

Key words: Asthma, SCF, C-kit, gene expression






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