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Review Article

SRP. 2020; 11(1): 42-50


Experimental Study for Loading & Unloading of Cefixime on Activated Carbon as Drug Delivery

SALIH A. RUSHDI, SHAHAD F. HAMEED.

Abstract
Over the past decade, drug carries of various kinds have been used in the field of drug release control operations. It is agreed that drug carries maintain the concentration of drugs within the required range for a long period of time and reduce the toxicity resulting from the use of overdoses and the ability to direct the drug to the affected area. In this research activated carbon was used as an organic carrier in two different sizes (0.6 m size with surface area 544.4704 m2/g and 11.042 nm size with surface area 985.6013m2/g ) and cefixime was used as a drug model ,The loading process was based on the adsorption between the surfaces of activated carbon molecules and the drug molecules dissolved in ethanol. The maximum efficiency of the experiments was 73% when the carbon in nanoparticle size and the carrier-to-drug ratio weight were 1.5, The unloading process was studied by studying the mass transfer coefficient and knowing the effect of the variables on its value ,these variables are time and temperature in addition to the PH value of the solution. The highest value of the mass transfer coefficient was obtained at the beginning of the unloading time ,at temperature 37 co and at PH 1.5 for dissolution medium .added to it proved that when using nanoparticle sizes, the unloaded (release) of the drug is more controlled over time than if the size of the carbon particles and the latter are better than if the drug is pure.

Key words: Drug delivery, activated carbon, cefixime, mass transfer coefficient



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