Hesperidin, famously known as Vitamin P and Diosmin are the popular, abundant and inexpensive products obtained from citrus agronomy. With no signs of toxicity, these flavonoids are largely consumed as a dietary supplement and have a long history of medication. In various studies, conducted on Hesperidin & Diosmin have reported a number of protective potentials such as neuroprotective, cardio protective, hepato protective, anti-inflammatory, antioxidant, lipid lowering, and insulin-sensitizing properties. Despite their enormous remedial potential, the poor aqueous solubility and minimal bioavailability are some major curbs that restrict the utilization of Hesperidin and Diosmin in medical perception. Though, future of medicine belongs to synthesis and usage of nano-dimensioned materials by means of nanotechnology which has been revolutionising the delivery of different constituents with much more precision oriented delivery to the target.
This review highlights the in vivo and clinical studies to elucidate the therapeutic and pharmacological properties of Hesperidin & Diosmin that have been reported since 2015, also displays the gaps in our knowledge about both the compounds and the growing influence of nanotechnology to overcome the characteristic limitations which deserves more exploration.
Flavonoids, Diosmin, Hesperidin, Nano formulation
Post-synthesis modification of covalent organic frameworks for ultrahigh enrichment of low-abundance glycopeptides from human saliva and serum.
Xie Z, Yan Y, Tang K, Ding CF
Talanta. 2022; 236(): 122831
Impact of pesticide formulation excipients and employed analytical approach on relative matrix effects of pesticide determination in strawberries.
Kasperkiewicz A, Lendor S, Pawliszyn J
Talanta. 2022; 236(): 122825
Development of Nano-Conjugated DNA Vaccine Against Edwardsiellosis Disease in Fish.
Bedekar MK, Kole S
Methods in molecular biology (Clifton, N.J.). 2022; 2411(): 195-204
Vacuum-assisted headspace thin-film microextraction: Theoretical formulation and method optimization for the extraction of polycyclic aromatic hydrocarbons from water samples.
Yiantzi E, Murtada K, Terzidis K, Pawliszyn J, Psillakis E
Analytica chimica acta. 2022; 1189(): 339217
Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells.
Liu Q, Luo Y, Zhao Y, Xiang P, Zhu J, Jing W, Jin W, Chen M, Tang R, Yu H
Bioactive materials. 2022; 8(): 478-493