A pharmaceutical industry wastewater in Wonogiri district, Central Java, Indonesia, contains high Fe and Mn concentration that should be reduced to1.0and 0.5 ppm to implement the Indonesian Ministry of Environment Law No 5 of 2014.Thisstudy aims to evaluate the effectiveness of combined activated allophanic and isol adsorption and type 4 Effective Microorganisms (EM-4) biosorption for Fe and Mn remediation. The allophanic and isol of Lawu volcano, Indonesia is activated using NaOH and molded into a tube, and theEM-4 is attached to bio ballsthen inserted in to the all ophanic and isol tube. This combined bioreactor system is submerged into the wastewater and operated in aerobic batch condition and set for 0, 6, 12, 18, 24 hours at 28, 32, 37and 46oC. The concentrations of iron were detected using the Indonesia National Standard Method (SNI) No.6989-4-2009and manganese by SNI No. 03-6855-2002.The results showed a decrease from 1.684 to 0.188 ppm of iron, and manganese from 0.993 to 0.148 ppmat37oC after 24 hour operation.
Key words: waste water, bioabsorption, bioreactor