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Review Article

JCR. 2020; 7(1): 11-15


ACCREDITING GENE THERAPIES WITH NON-VIRAL LIPID NANOPARTICLES DELIVERY SYSTEM AND ITS RELATED PERTINENCE

SAMEER SHARMA, SAROJ YADAV, SIBI G*.

Abstract
Gene therapy also called human gene transfer is defined as to cure a particular disease by relocate the genetic material. Lipid nanoparticles serve as the foremost advanced delivery method in consideration of genetic medication. Lipid nanoparticles are currently the advance and remarkable in non-viral delivery process for permissive the analytical potential of genetic medication. Genetic medication supported nucleic acids (RNA and DNA) because they contain uncommon remedial potential as just about any illness are often cured by silencing prophylactic cistron and damaged genes as well as convey a favourable protein. In this review, an attempt was made to clarify the progress in non-viral lipid nanoparticle delivery methods that have enticing properties. Therefore, the therapies supported nucleic acid polymers need refined delivery method to convey these macromolecules to the inside of target cells. Finally, we tend to address current application of lipid nanoparticles science as enforced to genetic medication.

Key words: lipid nanoparticles, non-viral gene delivery, gene therapy, cationic liposomes



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