Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Review Article

SRP. 2019; 10(2): 53-59


THE IMPACT OF ATORVASTATIN RELOAD IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION AND ITS CORRELATION WITH THE TOLL-LIKE RECEPTORS

Najah R. Hadi, Alaa Ghazi, Khalid I. Amber, Sahar A.Majeed, Hayder A. Al-Aubaidy.

Abstract
The present study aims to evaluate the effect of pre percutaneous coronary intervention (PCI) atorvastatin reload on peripheral monocyte of toll-like receptor 2 and toll like receptor 4 expression and their correlation with cardiac injury markers (troponin I and creatine kinase Muscle brain isoenzyme) in a patient with stable angina. A double-blind randomized prospective trial in which 60 stable angina patients scheduled for an elective PCI were randomly allocated into two groups after, control group: 30 patients who received low dose atorvastatin 40 mg daily without reload. Atorvastatin reloads group: 30 patients who were already on the usual dose of atorvastatin with further 80 mg and 40 mg at 12 & 2 hrs. before PCI, respectively. TLR2 and TLR4 levels were assayed in peripheral monocyte by flow cytometry and cardiac troponin I, CK-MB, MCP-1 and HMG-box-1 protein were also measured before and at 4 hrs, 12 hrs after PCI. Stent implantation was associated with an elevation in TLR2 and TLR4 expression in peripheral monocyte in both study groups after stenting but significantly higher expression level was observed among the control group ( ) at 4 hr and 12 hr post PCI. Inflammatory cytokine (HMG Box-1 protein MCP-1) were remarkably elevated after stenting in both study groups ( ) but significantly higher in control group as compared to the atorvastatin reload group ( ) also myocardial injury markers (CKMB, troponin I) were significantly higher in control group than atorvastatin reload group ( ).there is a positive correlation between TLR2 and TLR4 expression with serum level of cardiac troponin I and CK-MB
Atorvastatin reload before coronary artery interventions attenuate toll-like receptor 2 and 4 expressions on peripheral monocyte and significantly reduce serum level of HMG-box-1protein, MCP-1 and cardiac injury markers (CK_MB and cardiac troponin I) and Increase peripheral monocyte expression of TLR2 and TLR4 associated with elevated serum level of cardiac injury markers (CK_MB and cardiac troponin I).

Key words: Atorvastatin, percutaneous coronary intervention10.5530/srp.2019.2.10



Similar Articles

Global, regional and national burden of lung cancer and its attributable risk factors in 204 countries and territories, 1990-2019.
Yuan J, Sun Y, Bu X, Ren H, Chen M
European journal of cancer prevention : the official journal of the European Cancer Prevention Orga. 2021; ():

Rapid decline in cardiac function in diabetic patients with calcified coronary artery disease undergoing hemodialysis: two case reports.
Yamaoka H, Yamamoto T, Endo D, Shimada A, Matsushita S, Asai T, Amano A
BMC cardiovascular disorders. 2021; 21(1): 271

A prospective study to compare the operative outcomes of minimally invasive proximal and distal chevron metatarsal osteotomy for moderate-to-severe hallux valgus deformity.
Choi JY, Kim BH, Suh JS
International orthopaedics. 2021; ():

Necrotizing pancreatic pseudocyst induced by percutaneous transhepatic cholangiography & endoscopic retrograde cholangiography for biliary strictures after liver transplantation: Case report.
Lee MR, Yang JD, Ahn SW, Yu HC
Annals of hepato-biliary-pancreatic surgery. 2021; 25(Suppl 1): S263

Percutaneous tibial nerve stimulation in patients with severe low anterior resection syndrome: randomized clinical trial.
Marinello FG, Jiménez LM, Talavera E, Fraccalvieri D, Alberti P, Ostiz F, Frago R, Blanco A, Pellino G, Espín-Basany E
The British journal of surgery. 2021; ():


Full-text options


Add your Article(s) to Indexes
• citeindex.org






ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.