Background: Health-related quality of life (HRQoL) is an important indicator of treatment outcomes for patients with Parkinsonís disease (PD). Accordingly, this study determined the HRQoL of PD patients in the context of Vietnam and explored whether disease duration and disease stage affect the HRQoL of the Vietnamese subjects.
Methods: The research assessed 268 PD patients whose conditions have had a mean duration of 8.46 years. Among them, 139 (51.87%) additionally suffered from motor fluctuations and/or dyskinesia. The evaluation was conducted using the 39-item Parkinsonís Disease Questionnaire (PDQ-39), which consists of eight dimensions that can be scored from 0 to 100. The higher the score, the worse the QoL of a patient.
Results: The comparison of the groups with and without motor fluctuations showed that the former scored higher in terms of mobility (MOB), activities of daily living (ADL), emotional well-being (EMO), stigma (STI), social support (SOC), and cognition (COG). A trend observed in this work was that high Hoehn and Yahr scores resulted in equally high PDQ-39 scores, except for the EMO and STI dimensions. The patients suffering
from the disease for more than 5 years had worse MOB, ADL, STI, SOC, and COG scores than those of the subjects grappling with PD for ‚Č§5 years. Conclusion: The PDQ-39 can determine a decrease in the QoL of PD patients, and such reduction is predicted by the occurrence of motor fluctuations.
Dyskinesia, Fluctuation, HRQoL, Quality of life, QoL, Parkinson, Vietnam.