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Review Article

JCR. 2014; 1(1): 1-9


DIFFERENT CHEMICAL, BIOLOGICAL AND MOLECULAR APPROACHES FOR ANTI-HYPERLIPIDEMIC THERAPY WITH SPECIAL EMPHASIS ON ANTI-HYPERLIPIDEMIC AGENTS OF NATURAL ORIGIN

ASHOK K SINGH, VINEY CHAWLA, SHAILENDRA K SARAF, AMIT KUMAR KESHARI.

Abstract
Elevated levels of serum cholesterol leading to atherosclerosis can cause enhanced risk factors for coronary artery diseases (CAD). Reduction in serum cholesterol levels reduces the risk of CAD, substantially. Medicinal chemists all around the world have been designing, synthesizing, and evaluating a variety of new bioactive molecules for lowering lipid levels. Even so, some patients in the high risk category fail to achieve recommended cholesterol levels and to bring about regression of the already existing atherosclerotic lesions with currently available medications. Thereby, development of novel approaches to battle the world epidemics of hyperlipidemia remains relevant. In addition to existing treatments, some other recent chemical, biological and molecular approaches for the development of novel antihyperlipidemics are discussed herein. But none of these approaches are currently approved for use in humans. Several ongoing agents are in their different stages of clinical trials, in expectation of promising antihyperlipidemic drugs.

Key words: Antihyperlipidemia, Atherosclerosis, Coronary heart diseases (CHD), Statins and Nonstatins.



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