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Review Article

JCR. 2016; 3(3): 5-12


SOLID LIPID NANOPARTICLES–A REVIEW

MANOJ KUMAR SARANGI, SASMITA PADHI.

Abstract
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine, and research, as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The incorporation of drugs into nanocarriers offers a new prototype in drug delivery that could be used for several levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site-specific drug delivery and hence have attracted the wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their advantages, limitations, and their possible remedies. Different production methods which are suitable for large-scale production and applications of solid lipid nanoparticles are described. The characterization of solid lipid nanoparticles is generally carried out by photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry, etc.

Key words: Solid lipid nanoparticles (SLN), Colloidal drug carriers, Homogenization, Scanning Electron Microscopy



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