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Review Article

JCR. 2017; 4(2): 10-21


GASTRORETENTIVE DRUG DELIVERY SYSTEMS: FROM CONCEPTION TO COMMERCIAL SUCCESS

HARSHIL P. SHAH, SHAILESH T. PRAJAPATI, C. N. PATEL.

Abstract
Despite the extensive advancements in the field of drug delivery, the oral route remains the favorable route for administration of therapeutic
actives. A success of oral controlled drug delivery systems is associated with reduced dosing frequency, decreased fluctuation in plasma drug
concentration profile along with improved patient compliance. However, they are also associated with challenges like shorter gastric residence
time, unpredictable gastric emptying and poor bioavailability for some molecules. This has initiated tremendous advancements in the field of
gastro-retention to achieve controlled release of drugs along with improved bioavailability of drugs with narrow absorption window as well as
localized action in the stomach and upper part of GIT. In present review, efforts have been envisaged to summarize our current understanding in the
field of gastro-retention and their in vitro as well as in vivo characterization. Present review also highlights commercially utilized gastro-retentive
technologies and some recently granted US patents in the field of GRDDS.

Key words: Gastro retentive drug delivery systems (GRDDS), Gastric emptying, Polymers, Bioavailability, Superporous hydrogels, Swellable matrix, Microballoons, Patents



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