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Review Article

JCR. 2019; 6(1): 1-5


RECENT THERAPEUTIC PROGRESS OF CHALCONE SCAFFOLD BEARING COMPOUNDS AS PROSPECTIVE ANTI-GOUT CANDIDATES

DEBARSHI KAR MAHAPATRA, VIVEK ASATI, SANJAY KUMAR BHARTI.

Abstract
Gout is a common form of arthritis characterized by severe and sudden pain for a long duration, swelling, tenderness, lingering discomfort, and
acute redness in the joint situated at the big toe due to the accumulation of monosodium urate (MSU) crystals. Though, at present these drugs have
limited pharmacodynamics benefits with the emergence of adverse effects. Therefore, the modern trend has perceived a shift towards the regular
use of natural products and tailored-approach, which have revolutionized the prescription pattern from traditional combinations to unexplored
classes of drugs. Natural product classes such as chalcones have received adequate attention for treating these severe ailments with a better margin
of safety. Chalcone or 1,3-diphenyl-2-propene-1-one or benzylideneacetophenone are the natural scaffold comprising of two aromatic rings
connected together by a three-carbon α, β unsaturated carbonyl link. The chalcone scaffold bearing synthetic (polyhydroxylated chalcones, 3,5,2,4-
tetrahydroxychalcone, trans-chalcone) and natural (sappanchalcone, okanin, hesperidin methylchalcone, quercetin chalcone, 4-hydroxyderricin,
isobavachalcone, xanthoangelol F, xanthoangelol, and xanthoangeleol B) compounds have been found to exhibit tremendous anti-gout activity by
completely suppressing the active disease proliferating enzyme, xanthine oxidase (XO) as well as by suppressing the activation of nuclear factor
kappa-light-chain-enhancer of activated B cells (NF-κβ), along with preventing the formation and influx of pro-inflammatory factors. The overview
glance of this scientific review will provide information to the scientists working in the pharmaceutical as well as allied science fields in fabricating,
screening, and exploring the abundant hidden chemical classes based on the provided structural, chemical, and miscellaneous aspects.

Key words: Chalcone, Gout, Inflammation, Xanthine oxidase, NF-κβ, Inhibition



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