To make a review by focusing upon characteristics of Sucralfate and its compatibility in Bilayer floating tablet for treatment of ulcer during pregnancy as Gastro Retaintive Drug Delivery System. This review focus on causes of stomach ulceration during pregnancy, characteristics study of Sucralfate and its compatibility with acceptance criterias of Bilayer Floating Tablet for treatment of ulceration during pregnancy .The ulcer protective Sucralfare is simpler and more effective H2 blockers. They can be implemented in case of pregnancy and administrated as combined form in empty stomach .Bi layer floating tablet is an approach of GRDDS. In Bi layered floating tablet ,Sucralfate can act as immediate release layer and absorbs at stomach and improve the bioavailability and which ideal dosage form attains the desired therapeutic concentration of drug in plasma and maintains constant frequency for entire duration of treatment.
Key words: Sucralfate, Ulcerprotective, , Bilayered floating tablet,GRDDS
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