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Review Article

SRP. 2010; 1(2): 175-181


A Clinical Update on Peroxisome Proliferator-Activated Receptors

Kumar A, Hasamnis A.

Abstract
The peroxisome proliferator-activated receptors (PPARs) belong to the group of nuclear receptor
superfamily. There are three subtypes of these receptors, PPAR alpha, beta, and gamma. These
receptors display differential tissue distribution and have specific functions. PPARs mainly regulate
lipid and carbohydrate metabolism. These receptors are also involved in inflammatory process,
reproduction, carcinogenesis, and other physiological processes in the body. Modulation of
these receptors has wide therapeutic potential in diseases like diabetes mellitus, obesity, heart
disease, atherosclerosis, cancer, inflammatory bowel disease, and many other conditions. In the
last few decades, numerous agonists and antagonists of PPARs have been discovered some of
which are now used in therapeutics. This review focuses mainly on the role of PPARs and their
ligands under different clinical conditions.

Key words: Peroxisome proliferator-activated receptors (PPARs) Lipid metabolism Diabetes mellitus Obesity Inflammation


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