Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Review Article

SRP. 2011; 2(2): 104-109

Annonaceous Acetogenins: The Unrevealed Area for Cytotoxic and Pesticidal Activities

Gupta A, Pandey S, Shah DR, Yadav JS, Seth NR.

The World Health Organization (WHO) redefined traditional medicine recently as comprising
therapeutic practices that have been in existence, often for hundreds of years, before
the development and spread of modern scientific medicine and are still in use today
(WHO, 1991).[1] Traditional healers have used the drugs of herbal, herbomineral, and animal origin
since the dawn of civilization to maintain health and treat disease. According to WHO, about 80%
of the worlds population use herbal drugs for their primary health care. These drugs are cheap
with no or less side effects. The Annonaceous acetogenins are C-32 or C-34 long-chain fatty
acids that have been combined with a 2- propanol unit at C-2 to form a terminal -unsaturated
-lactone. They often cyclize to form one, two, or three tetrahydrofuran or tetrahydopyran
rings near the middle of the alphabetic chain. To date, nearly 400 of these compounds have
been isolated from several genera of the plant family, Annonaceae. The potential application of
acetogenin molecules is linked to their marked properties: cytotoxic and antitumor (gigantecin,
bullatacin, and rolliniastatin) and pesticidal (asimicine and annonin). Biochemically, acetogenins
block mitochondrial respiration by inhibiting NADH-cytochrome-c oxidoreductase; this would
explain their pesticidal activity among others.

Key words: Annonaceae, Annonaceous acetogenins, Cytotoxic and pesticidal properties, NADH-cytochrome-c oxidoreductase inhibitor

Similar Articles

New benzyltriethylammonium/urea deep eutectic solvent: Quantum calculation and application to hyrdoxylethylcellulose modification.
Azougagh O, Essayeh S, Achalhi N, El Idrissi A, Amhamdi H, Loutou M, El Ouardi Y, Salhi A, Abou-Salama M, El Barkany S
Carbohydrate polymers. 2022; 276(): 118737

Passive social media use and psychological well-being during the COVID-19 pandemic: The role of social comparison and emotion regulation.
Yue Z, Zhang R, Xiao J
Computers in human behavior. 2022; 127(): 107050

Carbonaceous materials for removal and recovery of phosphate species: Limitations, successes and future improvement.
Recepoglu YK, Goren AY, Orooji Y, Khataee A
Chemosphere. 2022; 287(Pt 2): 132177

A Transfer Learning-Based Approach with Deep CNN for COVID-19- and Pneumonia-Affected Chest X-ray Image Classification.
Chakraborty S, Paul S, Hasan KMA
SN computer science. 2022; 3(1): 17

Biovalue in Human Brain Banking: Applications and Challenges for Research in Neurodegenerative Diseases.
Vedam-Mai V
Methods in molecular biology (Clifton, N.J.). 2022; 2389(): 209-220

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.

ScopeMed Web Sites