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Review Article

SRP. 2012; 3(1): 1-3

Is Hypertriglyceridemia a Key Detrimental Factor or Associative Triggering Factor for Cardiovascular Abnormalities?

Pitchai Balakumar, Lalita Babbar, Sanjeev Kalra, Nanjaian Mahadevan, Seetharaman Sritharan, Pawan Krishan.


Elevation of fasting plasma triglycerides above the normal level (150 mg/dL) is an indication of
hypertriglyceridemia (borderline high, 150–199 mg/dL; high, 200-499 mg/dL; very high, above
500 mg/dL). A plethora of experimental and clinical studies evidenced a perceptible association
between hypertriglyceridemia and cardiovascular disease. Hypertriglyceridmia could lead to
endothelial dysfunction, atherosclerosis, hypertension, and ischemic heart disease. In addition,
studies have demonstrated the myocardial susceptibility to ischemia-reperfusion injury in the
hypertriglyceridemic condition. Importantly, hypertriglyceridemia alone may cause cardiovascular
abnormalities like atherosclerosis even in absence of hypercholesterolemia. It is worth-mentioning
that a pharmacological reduction in triglyceride levels diminishes the cardiovascular disease
pathogenesis. It is a subject of contemporary interest to detail whether hypertriglyceridemia a
key detrimental factor or an associative triggering factor for cardiovascular abnormalities. This
review will discuss the potential role of hypertriglyceridemia in the pathogenesis of cardiovascular

Key words: Atherosclerosis, coronary artery disease, endothelial dysfunction, hypertension, hypertriglyceridemia, ischemic myocardial injury

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