Depression is among the common psychiatric disorders, therefore the common pathways
and pathogenesis associated with depression is required to be studied. In few years, role of
5-hydroxytryptamine-1A/B (5-HT1A/B) receptors in depressive disorders have been revealed. Both
preclinical and clinical studies reported that the potential agonist and antagonist at 5-HT1A/B
receptors have significant modulatory effects in depression. However, the collective details
regarding the involvement of 5-HT1A/B receptors and the molecular pathways associated in
depression is lacking. Thus, the present review evidence the link between 5-HT1A/B receptors in
the brain and depression, the possible pathways involved and their alterations in depression.
Further, it reviews the preclinical evidences of 5-HT1A/B receptor modulators as antidepressant
agents and their effectiveness. The current review also details the clinical relevance of 5-HT1A/B
receptors etiopathogenesis of major depression in humans.
Key words: 5-hydroxytryptamine1A/B receptor