The potential of mass spectrometry (MS) is often not fully utilized due to the absence of systematic workflow of mass spectral interpretation, partially caused by the lack of simplified literature for interpretation of soft ionization methods and collision induced fragmentation spectral data interpretation. Therefore, this review summarizes the rational work flows for the interpretation of mass spectral data generated using atmospheric pressure ionization (API) and collision induced dissociation (CID) fragmentation. Designed workflow will definitely assist the readers to interpret MS and MS/MS spectral data, especially for the structural elucidation of small drug molecules and their impurities.
Mass spectrometry (MS), Tandem mass spectrometry (MS/MS), Atmospheric pressure ionization (API), Collision induced dissociation (CID), Basic rules, Rational workflow
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