Applications of Co-Crystals in Pharmaceutical Drugs
Mikal Rekdal, Aravind Pai, Ravi Choudhari, Muddukrishna Badamane Sathyanarayana.
Co-crystal synthesis has become a field of high interest in the last decade. This category of solid forms has a variety of applications in industries such as textile, paper and electronics. For many purposes co-crystals will have superior properties in comparison to traditional salt crystals. This review article will focus on the application of co-crystals in pharmaceutical drugs. Co-crystals have opened doors to rein-troduce previously poor performing bioactive ingredients in new and improved solid structures. They have also allowed for the introduction of a new range of compounds for pharmaceutical therapy. Most importantly, co-crystals can create new medicines with increased solubility and hence improve the effi-ciency and safety of the treatment.
Key words: Co-crystal, Solid state characterization, Solubility, Stability, Xrd, Moisture.