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Review Article

SRP. 2018; 9(1): 49-54


A Systematic Review on Pharmacological Activities of 4-Methylumbelliferon

Yasmeen Al-Majedy, Abdul Amir Kadhum, Hiba Ibraheem, Ahmed Al-Amiery, Ahmed Abdel Moneim, Abu Bakar Mohamad.

Abstract
Umbelliferon, the natural crenelated coumarin distributed in the plants of a
piaceae family, has shown various biological activities, especially as a cancer chemo preventive agent. Coumarins have been categorized as a member of family of benzo-pyrone, that consist of pyrone ring united to benzene
ring. The benzo-pyrones may be sectioned to alfa type that coumarins
belong and the gama type that flavonoids have been major members.
Coumarins are chemical entity which has being synthesized in the past few years many forms of its derivatives; the entity provides the principal origin
of motivating to numerous chemist to investigate its diverse medical
efforts especially with regards to the anticoagulant activity. In present article we review recent 4-Methylumbelliferon, (4-MU) that are synthesized with
it pharmacological activities antioxidant, anti-inflammatory, antimicrobial activity, ant hepatitis, hepatoprotective, anticancer, antipyretic and analgesic
activity.

Key words: 7-hydroxy-4-mehtyl coumarin, 4-Methylumbelliferon, 4-MU, Antioxidant, Antitumor, Anti-inflammatory, Antimicrobial, Anticoagulant, Anticonvulsant activity.



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