Currently, the trends of alternative and complementary medicine are
highly developed. In the last few decades, the National Health Statistics
Report (NHSR) in America has shown a substantial increase in the use of
alternative and complementary drugs. The use of herbs as medications
or supplementations should result from a right decision between patient
and physician regarding potential risks, benefits, and other alternatives.
Although many herbs exhibit promising effects, most herbs have not been
yet scientifically approved, including their molecular mechanism process.
In this review, Aloe barbadensis Miller or popularly known as Aloe vera
will be discussed as a potential local medicinal plant from cellular and
molecular mechanisms aspect. Thorough studies over the last few decades
have demonstrated that Aloe vera possesses various bioactive compounds
that are responsible for its medicinal properties. G1G1M1DI2 glycoprotein
fraction, for example, as one of the bioactive compound found in this plant,
has shown to accelerate the wound healing process. The present review
reports the findings of the underlying cellular and molecular mechanisms
of Aloe vera pharmacological activity from the extensive literature search
and our previous reports. This review may help to promote local medicinal
plant such as Aloe vera in order to improve its value and utilization in the
Aloe vera, molecular, cellular, mechanism.