For more than 20 years, since 1993, the Hungarian National Institute
of Pharmacy and Nutrition has been conducting a research on the
mechanisms of antitumor activity of light water (deuterium depleted
water DDW). Long-term randomized clinical trials in numerous treatment
centers in Hungary in compliance with the Good Clinical Practice (GCP)
indicate a high sensitivity of tumor cells to lower levels of deuterium (D) in
the body. The replacement of the ordinary water (D)/H = 140 ppm) by the
light one (D/H = 20-105 ppm) is accompanied by a decrease in the size
of the tumor, gradual necrosis of tumor cells, an increase in the median
survival of cancer patients (prostate cancer, breast cancer, lung cancer,
etc.). The content of deuterium in the body at the level of 10-12 mmol is
an order of magnitude higher compared to essential trace elements, which
makes it possible to predict its key role in biochemical processes. Indeed,
mass-spectrometric analysis shows that deuterium bioaccumulation in the
human body depends on its phenotype. In contrast, when drinking water is
replaced with DDW, the deuterium content in aqueous extracts of biological
blood samples, muscle and liver tissues of laboratory animals goes down.
The use of DDW as a prophylactic agent and many experimental results
obtained in vitro and in vivo in China, Japan, the USA, Romania, and the
Russian Federation make it possible to recommend DDW for use as a safe
additional agent in the treatment of cancer.
Key words: DDW, deuterium depleted water, tumor cells.
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