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Case Report

Med Arch. 2019; 73(4): 285-287

Madelung’s Disease Leading to Presenile Dementia in a Non-alcoholic Patient

Georges El Hasbani, Richard Assaker, Sutasinee Nithisoontorn, William Plath, Edgardo Olvera Lopez, Jose Vargas Gamarra, Ahmad Kofahi, Christopher Bertely, Vihren Dimitrov.


Introduction: Madelung’s disease (MD) is a rare disorder of unknown etiology defined as the presence of multiple and symmetrical fatty accumulations most commonly involving the upper trunk, neck, and head. Excessive alcohol ingestion has been linked traditionally to the pathogenesis of the disease. The central and peripheral nervous system could both be affected. Presenile dementia, without alcohol abuse, has been rarely reported in the literature as a complication. Aim: The aim of this case report is to highlight that multiple symmetric lipomatosis can be complicated by presenile dementia even if the patient is non-alcoholic. Case Report: This case report describes a middle age non-alcoholic woman who presented for increased forgetfulness. Brain CT scan showed cerebral and cerebellar atrophy inappropriate for her age. Despite being started on anticholinergic drug, her MMSE decreased 3 points in 1 year. Conclusion: Clinicians should consider early onset dementia as a potential complication of Madelung’s disease even in patients with no preceding history of alcoholism. A brain MRI and MMSE can aid with identifying such a complication.

Key words: Multiple symmetric lipomatosis; presenile dementia; alcoholism.

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