Influence of Dexamethasone on some Metabolic and Thyroid Hormones in Gravid Yankasa Sheep and Sahel GoatsDauda YAHI, Yelwa MBAYA, Hannah MADZIGA, Isaac OMEH, Peter MSHELIA, Mohammed TIMTA, Nicholas OJO, Gideon MSHELIA.
Studies have shown that dexamethasone improves nutrient metabolism and could alleviate gestational hypoglycaemia commonly reported during pregnancy in yankasa sheep and Sahel goats. Nonetheless, the influence on thyroid hormones and other metabolic hormones in these species has not been investigated. This study investigated the influence of dexamethasone on thyroid and some metabolic hormones in gravid yankasa sheep and Sahel goats. Thirteen healthy adult Sahel goats comprising 12 does and 1 buck and 13 yankasa sheep comprising of 12 ewes and 1 ram were used for this study. They were synchronized using cloprostenol (Estrumate®). Pregnancies were achieved through natural mating and treated with dexamethasone (0.25mg/kg body weight) on days 1, 3 and 5 during first trimester; day 51, 53 and 55 during second trimester, and day 101, 103 and 105 during the third trimester. Blood samples were collected biweekly and were used for the analysis of TSH (thyroid stimulating hormone), cortisol, insulin, T3 (triiodothyronine) and T4 (thyroxine),. Dexamethasone significantly increased T3 and insulin, while on the other hand, decreased TSH concentrations, in both species. Similarly, dexamethasone significantly decrease T4 concentration in sheep but has no significant effect on T4 concentration in goats. With regards to cortisol, dexamethasone significantly increased serum cortisol level in sheep but significantly decreased same in goats. It was concluded that the rise in T3 implies important consequences for foetal maturation in both species, while the increase in cortisol implies that dexamethasone has potential pregnancy risk in yankasa sheep. Therefore dexamethasone should be avoided during pregnancy in yankasa sheep.
Dexamethasone, goats, metabolic hormones, sheep, thyroid hormones
SUBMIT YOUR ARTICLE NOW