Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Research



Treatment with Methanol Root Extract of Mirabilis jalapa Suppresses Postprandial Hyperglycemia and Dyslipidemia in Diabetic Rats

Mas'ud Eneji Sadiq, Aminu Lailaba Abubakar, Hamza Yunusa Abubakar, Hassana Adio.

Abstract
The present study demonstrates the postprandial hypoglycemic effects of methanol root extract of Mirabilis jalapa. Alloxan induced diabetic rats were treated with 200 mg/kg body weight of the extract for 9 days at 12 hourly intervals. The experiment was designed to assess both fasting and 2 hour postprandial blood
glucose levels. Lipid profile and liver function biochemical analyses were conducted using serum obtained from the experimental animals sacrificed after 10 days. The results showed a marked difference in blood glucose levels postprandial in the diabetic group treated with the extract (DTM) (11.02 1.42 mmol/L) when compared with the diabetic untreated group (DU) (19.80 5.37 mmol/L). Similar trends were observed for the fasting blood glucose which remained elevated in the DU group throughout the experiment but was maintained at comparable levels (4.70 6.82 mmol/L) between healthy control group (HU) and all other groups treated both with extract and standard drug metformin. Triglyceride levels of diabetic groups treated with the extract were also observed to fall within comparable limits with the HU group (30.79 4.76 65.95 2.42 mg/L). In conclusion, treatment with methanol root extract of Mirabilis jalapa suppresses hyperglycemia postprandial and probably promotes slow progression to dyslipidemia in experimentally induced diabetes in rats.

Key words: Mirabilis jalapa, Diabetes mellitus, Hypoglycemia, metformin



Full-text options

Full-text Article




Advertisement
Archives of Clinical and Experimental Surgery (ACES)

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.