An Overview on Gastro Retentive Floating MicrospheresShah Chainesh*, Aundhia Chintan, Ramani Vinod, Shah Nirmal, Chauhan Sachin, A. K.Seth, Ghelani Tejas, Vegada Rajnikant. Sumandeep Vidyapeeth, Piparia, Waghodiya..
Once important aspect for successful controlled oral drug delivery is its complete absorption through gastrointestinal tract (GIT) mainly by passive diffusion. Oral controlled dosage form are not suitable for many drug having narrow therapeutic window in upper part of GIT (stomach and small intestine) due to less transit time in these anatomical portion thus drug is release in short time in non-absorbing distal segment of GIT, which ultimately lead to poor bioavailability of drugs. In recent years scientific and technological advancements have been made in the research and development of controlled release oral drug delivery systems by overcoming physiological adversities like short gastric residence time and unpredictable gastric emptying time. Floating Drug delivery system (FDDS) are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. This review also summarizes various sophisticated and modern evaluation parameter for floating microspheres. Thus floating drug delivery systems seems to be the promising delivery systems for control release of drugs.
Key words: Floating drug delivery systems, GIT, residence time, in-vitro, hydro dynamically balanced systems