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Review Article

IJPRT. 2018; 8(1): 1-11

Side reactions in peptide synthesis: An overview



Peptide synthesis involves condensation of two or more amino acids which seems to be easier but requires
specialized techniques. Since all the amino acids have basic skeleton but vary in their side chains, and their nature such
as acidic, basic or neutral depending on the presence or absence of functional groups, these side chains are prone to
side reactions during the process of synthesis either due to interaction with the solvent used for synthesis or during
the process of the deprotection of the specific groups. It could also occur due to lower rate of reaction where the
amino acids reacting forms byproducts leading to the lesser yield of the desired peptide chain. In the present
document, the side reactions that occur are described in brief with their mechanism. All the images of the reactions in
this document were drawn using ChemDraw software and have been made strong efforts to make the explanations
to be clear and easier to understand.

Key words: Peptide synthesis, functional groups, side reactions, mechanisms

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