Abstract

The antimicrobial activity of Caesalpinia bonducella extracts, and their isolated phytoconstituents, ß-Sitosterol and methyl (4E)-5-{2-[(1E)-buta-1,3-dien-1-yl]-4,6 dihydroxyphenyl} pent-4-enoate was evaluated on gram-positive and gram-negative bacteria. The antibacterial activity of the extracts and isolated compounds were found to have moderate to significant. The maximum activity was observed on bacteria P. aeruginosa. Further isolated compounds were subjected to molecular docking studies of the Bacterial DNA Gyrase. The in silico study showed the inhibition of DNA Gyrase with a docking energy of -6.4 and three hydrogen bonding. The isolated compounds may be considering as good inhibitors of bacterial DNA Gyrase.

Key words: Caesalpinia bonducella, antimicrobial activity, molecular docking study.