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Significance of serum uric acid level in Pre-Diabetic and Diabetic patients

Seraj Ahmed Khan, Saroj Mandal.

Abstract
Introduction: Diabetes is a group of metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Research has shown strong links between uric acid levels and medical conditions that are related to insulin resistance that increases the chance of acquiring diabetes. Though discrepancies in result have also been reported. Aim: This study aims to investigate the role of uric acid in diabetic and prediabetic subjects and compare them with euglycemic control. Methods: In this hospital-based comparative cross-section study, 220 subjects were enrolled, out of which 76 were diabetic, 74 prediabetic and 70 euglycemic control. The male and female ratio was almost the same in the 3 groups. Diabetes mellitus was defined as fasting glucose ≥126 mg/dl, non-fasting glucose ≥200 mg/dl, or use of oral hypoglycemic medication or insulin. Three ml fasting blood samples were collected and analyzed for fasting blood glucose (FBG), and uric acid (UA). Two-hour post-meal blood was collected for postprandial glucose (PPG) estimation. For comparison of variables among the group's chi-square for categorical and student t-test, Mann Whitney U and ANOVA for continuous data was applied. Pearsons correlation coefficients were used to determine the relationships between variables. P value < 0.05 was considered as significant. Results: Mean age of the diabetic, prediabetic and euglycemic control was 56.16 12.58, 53.69 14.92, and 48.97 14.74 years respectively and the difference was statistically significant (p=.009). The mean UA level was also statistically different in the three groups (p=.010), the highest level (7.50 2.24 mg/dl) in diabetic patients and lowest level (6.44 2.06 mg/dl) in euglycemic control. There was a positive and significant correlation between uric acid and FBS, PPG (r=.253, p=.002; r=.134, p=.048) in the participants. Conclusion: We observed a significant association of uric acid in diabetic, prediabetic and euglycemic control, however, it is not associated with the outcome of diabetes.

Key words: Diabetic, Prediabetic, Uric acid, Fasting blood glucose



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