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Original Research

Natl J Med Res. 2018; 8(1): 21-24


Effectiveness of triple drug fixed dose combination inhalation therapy in severe chronic obstructive pulmonary disease

Vrunda Bhupendrabahi Patel, Palak Harshvardhan Bhatt, Nikita Vinodbhai Rajguru, Savita Jindal, Sanjay Tripathi, Vishakha Kalpesh Kapadia.


Abstract

Introduction: According to GOLD 2018 guidelines, inhaled corticosteroids are recommended along with long acting muscarinic antagonist (LAMA) and long acting beta-2 agonist (LABA) inhaler medications in Group D COPD patients who show frequent exacerbations and symptom severity. Therefore, the use of triple drug inhaled medication in such severe COPD patients become necessary.
Method: 25 severe COPD patients were included in this hospital based study. Before initiating the triple drug inhaled medication the baseline parameters such as spirometry ( FEV1), exercise tolerance (6 minute walking distance) and symptom control(CAT score, MMRC dyspnoea grading) are measured. 2 monthly follow-up till 6months of the study period is done. At each visit all the baseline parameters are reassessed.
Result: There is statistically significant (p=

Key words: Keywords: COPD, triple drug, MMRC, CAT Scoring






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