Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Article



Biological activity of Passiflora edulis f. Flavicarpa ethanolic leaves extract on human colonic adenocarcinoma cells

Valentina Ramirez, Sandra Sulay Arango, Maria Elena Maldonado, Diego Uribe, Johanny Aguillon, Jenny Paola Quintero, Nelsy Loango.

Abstract
Studies of extracts and phytochemicals from Passiflora genus have shown promissory biological activity for cancer chemoprevention; thus, in this work it was evaluated the anticancer potential of the ethanolic extract of Passiflora edulis f. Flavicarpa leaves, over Caco-2 and SW480 colorectal adenocarcinoma cells. The effect of the extract on cell viability was evaluated by MTT and its antiproliferative activity was assessed by clonogenic assays. Additionally, by flow cytometry approaches, it was evaluated the apoptosis-inducing effect and cell cycle regulation. In this way, it was established the half maximal inhibitory concentration (IC50) of the extract over both cell lines and also, it was observed the inhibition of cellular proliferation after 24 hours of exposure to the extract. On the other hand, we observed that the extract induced cell death-mechanisms, by the increasing of the proportion of necrotic and apoptotic cells; furthermore, the extract altered the distribution of cell cycle phases by increasing SubG1 and G2/M populations. Altogether, these results suggest that P. edulis is a potential source of phytochemical compounds with anticancer properties, for the management of colorectal cancer.

Key words: Passiflora edulis, ethanolic leaves extract, phytochemicals, anticancer potential, colorectal cancer



Similar Articles

Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease.
Goulding SR, Anantha J, Collins LM, Sullivan AM, O'Keeffe GW
Neural regeneration research. 2022; 17(1): 38-44

Effects of selenium-containing compounds on Cu/Zn-induced neuronal cell death and potential application as therapeutic agents for neurological diseases.
Tanaka KI, Shimoda M, Kawahara M
Neural regeneration research. 2022; 17(2): 311-312

A sensitive electrochemiluminescence biosensor for assay of cancer biomarker (MMP-2) based on NGQDs-Ru@SiO2 luminophore.
Fan X, Wang S, Liu H, Li Z, Sun Q, Wang Y, Fan X
Talanta. 2022; 236(): 122830

SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology.
Marques RF, Duncan KE
Neural regeneration research. 2022; 17(2): 266-270

Therapeutic potential of translocator protein ligands for age-related macular degeneration.
Li X, He Z, Shu X
Neural regeneration research. 2022; 17(4): 793-794


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.



ScopeMed Web Sites