Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Research



Prognostic and predictive values of human enhancer of filamentation1 (HEF-1) and Sparc/osteonectin, cwcv, and kazallike domains proteoglycan 1 (SPOCK1), in transitional cell carcinoma (TCC) of the urinary bladder; an immunohistochemical study

Mouhamed A. Fouad, Mona Saeed Mohamed.

Abstract
Background: Transitional cell carcinoma (TCC) of the bladder forms about ninety percent of all bladder cancer cases. There is a need to discover novel management strategies for such cancer as it has high incidence, high invasion and metastasizing rates. Human enhancer of filamentation1 (HEF-1) that is a cytoskeletal protein is an important signaling mediator of plethora of normal cellular events. Sparc-osteonectin; cwcv & kazallike; domains- proteoglycan 1 (SPOCK1), have many roles in normal cell cycle control, DNA repair and apoptosis.
Aim of the work: to detect expression of HEF-1 & SPOCK-1 in TCC using immunohistochemistry, then correlate combined expression of markers with pathological, clinical and prognostic parameters of patients with this cancer type.
Methods: we detected HEF-1 & SPOCK-1 expression in sections from 40 paraffin blocks from forty TCC patients using immunohistochemistry. Then we have correlated combined expression of markers with pathological, clinical and prognostic parameters of patients with this cancer type.
Results: The expression of HEF-1 in TCC was signifi¬cantly positively associated with lower degree of differentiation and stage of the cancer (p

Key words: HEF1, SPOCK-1, immunohistochemistry, survival, Transitional cell carcinoma, prognosis.



Full-text options

Full-text Article




Advertisement
Journal of Molecular Pathophysiology

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.