Home|Journals|Articles by Year|Audio Abstracts RSS - TOC

Original Research


Ranny Beatriz de Carvalho Holanda Leite, João Cláudio da Costa Urbano, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Aldo da Cunha Medeiros, Ítalo Medeiros de Azevêdo, Vanessa Santos de Arruda Barbosa, Cecília Maria de Carvalho Xavier Holanda.


The human toxoplasmosis is a disease caused by the parasite Toxoplasma gondii that can affect the growing baby in pregnancy and it is the most common CNS infection in patients with AIDS. Its treatment is made by the synergistic association of the drugs pyrimethamine (PM) and sulfadiazine (SDZ). Objective: the aim of this study was to evaluate if the use of the combination of PM and SDZ changes the sodium pertechnetate (Na99mTcO4-) biodistribution in non-infected animals by the T. gondii. It was used 24 male Swiss mice equally divided into 4 groups: 1 control group and 3 treated groups. Methods: the control group received 0.5 mL of distilled water; the treated group 1 received 0.5 mL of a PM solution; the treated group 2 received 0.5 mL of a SDZ solution and the treated group 3 received 0.5 mL of the PM+SDZ, all by the gavage method for 10 days. On the 10th day and 1 h after the last dose, all groups received 0.1mL of Na99mTcO4- (0.66MBq) via the femoral vein. After 40 min, the animals were euthanized, and blood and brain samples were isolated. The percentage of total activity injected per gram of organ (%ATI/g) was calculated on the gamma counter. Statistical analysis were performed using the T-test, considering a level of significance of p

Key words: Anti-Toxoplasma drugs. Synergistic drugs. Sodium pertechnetate. Toxoplasma gondii. Sulfadiazine. Pyrimethamine.

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.