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Original Article

J Apither. 2018; 3(2): 31-35


Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model

İhsan Karaboğa.

Abstract
Aim: This study was conducted to explain the anti-inflammatory activity of caffeic acid phenethyl ester (CAPE) in an experimental rat thoracic trauma model. Materials and Methods: Forty adult (200 - 250 g) male Wistar albino rats were used. Rats were randomly divided into 4 groups; Control (n=10), Trauma model (n=10), Trauma model + CAPE (n=10) and CAPE (n=10) groups, respectively. CAPE treatment was administered intraperitoneally at a dose of 10 µmol/kg for seven days. At the end of the seventh day, the rats were sacrificed under anesthesia. Serum interleukin 1-beta (IL-1β), interleukin-6 (IL-6) and interleukin-10 cytokine levels were determined as pg/ml using the sandwich ELISA method. Results: In the trauma model, there was increased IL-1β and IL-6 and decreased pro-inflammatory IL-10 serum levels compared to the control group (p

Key words: Cytokines, Tumor necrosis factor alpha, Interleukine-6, Interleukine-10



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